Wissenschaftliche Publikationen  (ohne Patentschriften) 52. Unified theory of Alzheimer’s disease (UTAD): implications for prevention and curative therapy Journal of Molecular Psychiatry 2016 4:3; DOI: 10.1186/s40303-016-0018-8 51. Evolutionsbiologische Erklärung der Alzheimer-Entstehung. Mikronährstoffe in Prävention und Therapie Zs. f. Orthomol. Med. 2015, V.3, S.11-15 50. An EF hand mutation in Stim1 causes premature platelet activation and bleeding in mice. J. Clin Invest. 2007, V.117, S.3540-3550 49. Contribution of mucosal maltase-glucoamylase activities to mouse small intestinal starch alpha-glucogenesis.  J. Nutr. 2007, V.137, S.1725-1733 48. N-ethyl-N-nitrosourea-based generation of mouse models for mutant G protein-coupled receptors. Physiol. Genomics 2006, V.16, S. 209-217 47. Mutation of mouse Mayp/Pstpip2 causes a macrophage autoinflammatory disease. Blood 2006 Apr 15;107(8):3350-8. 46. Efficient and fast targeted production of murine models based on ENU mutagenesis. Mamm. Genome 2005 Jun;16(6):405-13. 45. Autoimmunity and inflammation due to a gain-of-function mutation in phospholipase C gamma 2 that specifically increases external Ca2+ entry. Immunity 2005 Apr;22(4):451-65. 44. Failure to degrade poly(ADP-ribose) causes increased sensitivity to cytotoxicity and early embryonic lethality. Proc Natl Acad Sci USA 2004 Dec 21;101(51):17699-704. 43. The dominant alopecia phenotypes Bareskin, Rex-denuded, and Reduced Coat 2 are caused by mutations in gasdermin 3. Genomics 2004 Nov;84(5):824-35. 42. Synergistic interaction of two independent genetic loci causes extreme elevation of serum IgA in mice. Genes Immun. 2004 Aug;5(5):375-80. 41. A novel missense mutation in the mouse growth hormone gene causes semidominant dwarfism, hyperghrelinemia, and obesity. Endocrinology 2004 May;145(5):2531-41. 40. Diverse psychotomimetics act through a common signaling pathway. Science 2003 Nov 21;302(5649):1412-5. 39. A mouse model for cystinuria type I. Human Molecular Genetetics 2003 Sep 1;12(17):2109-20. 38. Random mutagenesis in the mouse as a tool in drug discovery. Drug Discovery Today 2002 Dec 1;7(23):1175-83. Review 37. Isolation and biochemical characterization of LEAP-2, a novel blood peptide expressed in the liver. Protein Science 2003 Jan;12(1):143-52. 36. Deductive genomics: a functional approach to identify innovative drug targets in the post-genome era. Am. J. Pharmacogenomics 2002;2(4):263-71. Review. 35. Abnormal bone marrow stroma in mice deficient for nemo-like kinase, Nlk. Eur J Immunol. 2001 Dec;31(12):3580-7. 34. Only one nemo-like kinase gene homologue in invertebrate and mammalian genomes. Gene 2001 Oct 31;278(1-2):161-5. 33. Knock-out mouse for Canavan disease: a model for gene transfer to the central nervous system. J Gene Med. 2000 May-Jun;2(3):165-75. 32. Eomesodermin is required for mouse trophoblast development and mesoderm formation. Nature 2000 Mar 2;404(6773):95-9. 31. Identification of a mammalian angiopoietin-related protein expressed specifically in liver. Genomics 1999 Dec 15;62(3):477-82. 30. Cloning, chromosomal location, and expression analysis of murine Smarce1-related, a new member of the high-mobility 365 group gene family. Genomics 1999 Sep 1;60(2):172-8. 29. Mouse beta-defensin 3 is an inducible antimicrobial peptide expressed in the epithelia of multiple organs. Infect Immun. 1999 Jul;67(7):3542-7. 28. Construction of gene targeting vectors from lambda KOS genomic libraries. Biotechniques 1999 Jun;26(6):1150-6, 1158, 1160. 27. Structural and phylogenetic characterization of human SLURP-1, the first secreted mammalian member of the Ly-6/uPAR protein superfamily. Protein Sci. 1999 Apr;8(4):810-9. 26. A combined analysis of genomic and primary protein structure defines the phylogenetic relationship of new members if the T-box family. Genomics 1998 Feb 15;48(1):24-33. 25. The structural integrity of ROR alpha isoforms is mutated in staggerer mice: cerebellar coexpression of ROR alpha1 and ROR alpha4. Genomics 1997 Jul 1;43(1):78-84. 24. The nude gene encodes a sequence-specific DNA binding protein with homologs in organisms that lack an anticipatory immune system. Proc Natl Acad Sci USA 1997 Apr 15;94(8):3842-7. 23. Identification of interaction partners for the basic-helix-loop-helix protein E47. Oncogene 1997 Feb 27;14(8):891-8. 22. Suppression of apoptosis by nitric oxide via inhibition of interleukin-1beta-converting enzyme (ICE)-like and cysteine protease protein (CPP)-32-like proteases. J Exp Med. 1997 Feb 17;185(4):601-7. 21. Shear stress inhibits apoptosis of human endothelial cells. FEBS Lett. 1996 Dec 9;399(1-2):71-4. 20. Two genetically separable steps in the differentiation of thymic epithelium. Science 1996 May 10;272(5263):886-9. 19. Genomic Organization of the ATM gene. Genomics 1996 Apr 15;33(2):317-20. 18. Transcription factors that control development of the thymic microenvironment. Immunolology Today 1995 Dec;16(12):555-6. Review. 17. Dynamic changes in gene expression during in vitro differentiation of mouse embryonic stem cells. Cytokines Mol Ther. 1995 Jun;1(2):139-43. 16. An intragenic deletion in the human PTPN6 gene affects transcriptional activity. Hum Genet. 1995 Jun;95(6):713-5. 15. YAC/P1 contigs defining the location of 56 microsatellite markers and several genes across a 3.4-cM interval on mouse chromosome 11. Mamm Genome. 1995 May;6(5):321-31. 14. A rapid and efficient alternative to sonication in shot-gun sequencing projects. Trends Genetics 1995 Feb;11(2):39. 13. New member of the winged-helix protein family disrupted in mouse and rat nude mutations. Nature 1994 Nov 3;372(6501):103-7. 12. The sequence complexity of exons trapped from the mouse genome. Curr Biol. 1994 Nov 1;4(11):983-9. 11. Two large insert vectors, lambda PS and lambda KO, facilitate rapid mapping and targeted disruption of mammalian genes. Biotechniques 1994 Oct;17(4):770-5. 10. DNA methylation represses the murine alpha 1(I) collagen promoter by an indirect mechanism. Mol Cell Biol. 1994 Sep;14(9):5950-60. 09. Exon amplification from complete libraries of genomic DNA using a novel phage vector with automatic plasmid excision facility: application to the mouse neurofibromatosis-1 locus. Oncogene 1994 Aug;9(8):2169-75. 08. A yeast artificial chromosome contig on mouse chromosome 11 encompassing the nu locus. Eur J Immunol. 1994 Jul;24(7):1721-3. 07. Neomycin- and hygromycin-resistance expression cassettes containing an artificial triple-helix site and a synthetic lac operator facilitate restriction endonuclease cleavage at pre-defined sites and recovery of specific fragments from mammalian genomes. Mamm Genome. 1994 Mar;5(3):183-6. 06. Preparation of strand-specific cDNA from amplified sources. Trends Genetics 1993 Nov;9(11):376-7. 05. S-300 gel matrix irreversibly binds single-stranded nucleic acids. Trends Genetetics 1993 Oct;9(10):336-7. 04. NF-I/Sp1 switch elements regulate collagen alpha 1(I) gene expression. DNA Cell Biol. 1992 Jul-Aug;11(6):443-52. 03. Transcription factors nuclear factor I and Sp1 interact with the murine collagen alpha 1 (I) promoter. Mol Cell Biol. 1991 Aug;11(8):4065-73. 02. Biochemical and immunological evidence for a cardiodilatin-like substance in the snail neurocardiac axis. Proc Natl Acad Sci USA 1985 Nov;82(22):7762-6. 01. Phylogenetic aspects of cardiac hormones as revealed by immunocytochemistry, electronmicroscopy, and bioassay. Peptides 1985;6 Suppl 3:321-31.

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